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Description
Invivo anti-mouse 4-1BB (CD137) Recombinant mAbProduct Specification Host Rat Antigen 4 1BB (CD137) Synonyms Tumor necrosis factor receptor superfamily member 9; 4 1BB ligand receptor; T cell antigen 4 1BB; Ila; Ly63; Tnfrsf9 Location Cell membrane Accession P20334 Antibody Type Recombinant mAb Application in vivo 4 1BB stimulation, in vitro 4 1BB stimulation Reactivity Ms Purification Protein A Concentration 5 mg ml Purity >95% Determined by SEC HPLC Endotoxin <2EU mg Conjugation Unconjugated
Product Specification
| Host | Rat |
| Antigen | 4-1BB (CD137) |
| Synonyms | Tumor necrosis factor receptor superfamily member 9; 4-1BB ligand receptor; T-cell antigen 4-1BB; Ila; Ly63; Tnfrsf9 |
| Location | Cell membrane |
| Accession | P20334 |
| Antibody Type | Recombinant mAb |
| Application | in vivo 4-1BB stimulation, in vitro 4-1BB stimulation |
| Reactivity | Ms |
| Purification | Protein A |
| Concentration | 5 mg/ml |
| Purity | >95% Determined by SEC-HPLC |
| Endotoxin | <2EU/mg |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Ms |
Background
4-1BB (CD137, TNFRSF9) is a 39 kDa inducible costimulatory receptor expressed on activated T, NK, NKT and dendritic cells that, upon engagement by its trimeric ligand 4-1BBL or agonistic antibodies, recruits TRAF1/2 to trigger NF-κB, MAPK and PI3K–Akt signaling cascades, thereby enhancing proliferation, survival, cytokine production and cytotoxicity of CD8⁺ and CD4⁺ T cells and NK cells; its expression is tightly regulated (peaking 24–72 h post-activation and restrained by PD-1/CTLA-4 pathways) and its therapeutic agonism is exploited in immuno-oncology to overcome tumor-induced exhaustion, while antagonists are explored for autoimmune diseases.
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