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Description
Human TNF-β OneStep ELISA kitsProduct Specification Antigen TNF Immunogen Recombinant Protein Antibody Type Recombinant mAb Reactivity Hu Purification Protein A Stability & Storage 12 months from date of receipt reconstitution, 2 to 8'C as supplied. Kit Precision Intra assay: 5. 7% Inter assay: 7. 5% Sample type Cell culture supernatant, Serum, Plasma Assay type Sandwich (quantitative) Sensitivity 0. 110 ng mL Range 0. 156 pg mL 10 ng mL Recovery Cell culture supernatant: 86%
Product Specification
| Antigen | TNF-β |
| Immunogen | Recombinant Protein |
| Antibody Type | Recombinant mAb |
| Reactivity | Hu |
| Purification | Protein A |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8'C as supplied. |
Kit
| Precision | Intra-assay: 5.7%； Inter-assay: 7.5% |
| Sample type | Cell culture supernatant, Serum, Plasma |
| Assay type | Sandwich (quantitative) |
| Sensitivity | 0.110 ng/mL |
| Range | 0.156 pg/mL – 10 ng/mL |
| Recovery | Cell culture supernatant: 86% Serum: 111% Plasma: 115% |
| Assay time | 60 minutes |
| Species reactivity | Hu |
Background
Human Tumor Necrosis Factor-beta (TNF-β), also known as lymphotoxin-alpha (LT-α), is a pro-inflammatory cytokine primarily secreted by activated lymphocytes, including T cells, B cells, and NK cells. It signals through the TNF receptor 1 (TNFR1) and TNFR2, activating downstream pathways such as NF-κB, MAPK, and apoptosis cascades, which regulate immune responses and inflammation. Unlike TNF-α, which is produced by macrophages and other innate immune cells, TNF-β plays a specialized role in lymphoid organ development, host defense, and autoimmune pathogenesis. It contributes to the formation of secondary lymphoid structures and promotes cytotoxic T cell and B cell functions. Dysregulated TNF-β expression is associated with chronic inflammatory diseases, including rheumatoid arthritis and multiple sclerosis, making it a potential therapeutic target. Its dual role in immune regulation and pathology underscores its significance in both physiological and disease contexts.
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