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Description
LMPTP Rabbit Polyclonal AntibodyProduct Specification Host Rabbit Antigen LMPTP Synonyms Low molecular weight phosphotyrosine protein phosphatase; LMW PTP; LMW PTPase; Adipocyte acid phosphatase; Low molecular weight cytosolic acid phosphatase; Red cell acid phosphatase 1; ACP1 Immunogen Synthetic Peptide Location Cytoplasm Accession P24666 Antibody Type Polyclonal antibody Isotype IgG Application WB, IHC P, ICC Reactivity Hu, Ms, Rt, Mk Positive Sample HEK 293, K562, HeLa, HepG2,
Product Specification
| Host | Rabbit |
| Antigen | LMPTP |
| Synonyms | Low molecular weight phosphotyrosine protein phosphatase; LMW-PTP; LMW-PTPase; Adipocyte acid phosphatase; Low molecular weight cytosolic acid phosphatase; Red cell acid phosphatase 1; ACP1 |
| Immunogen | Synthetic Peptide |
| Location | Cytoplasm |
| Accession | P24666 |
| Antibody Type | Polyclonal antibody |
| Isotype | IgG |
| Application | WB, IHC-P, ICC |
| Reactivity | Hu, Ms, Rt, Mk |
| Positive Sample | HEK-293, K562, HeLa, HepG2, NIH/3T3, mouse brain, C6, rat liver, COS-7 |
| Predicted Reactivity | Ck, Pg, Or, Bv, Dr |
| Purification | Immunogen Affinity |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu, Ms, Rt, Mk |
| IHC-P | 1:200 | Hu |
| ICC | 1:500 | Hu |
Background
Low molecular weight protein tyrosine phosphatase (LMPTP), an 18 kDa cytosolic class II PTP encoded by the ACP1 gene, exists as two splice isoforms (LMPTP-A and LMPTP-B), is ubiquitously expressed with especially high levels in adipocytes, and functions as a negative regulator of insulin signalling by dephosphorylating the insulin receptor and its substrates; human genetic studies show that low-activity ACP1 alleles are associated with reduced glycaemia, while experimental knockdown or genetic deletion of LMPTP in obese mice improves glucose tolerance and insulin sensitivity—mainly via hepatic effects—demonstrating that LMPTP drives obesity-linked insulin resistance and type 2 diabetes, thus representing an attractive drug target for metabolic disorders.
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