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Description
APC Mouse Anti-Mouse CD45.1 Antibody (S-R521)Product Specification Host Mouse Antigen CD45R B220 Synonyms Receptor type tyrosine protein phosphatase C; Leukocyte common antigen (L CA); Lymphocyte antigen 5 (Ly 5); T200; CD45; Ly 5; Ptprc Location Cell membrane, Synapse Accession P06800 Clone Number S R521 Antibody Type Mouse mAb Isotype IgG2a,k Application FCM Reactivity Ms Positive Sample SJL mouse splenocytes Purification Protein A Concentration 0. 2 mg ml Conjugation APC Physical Appearance
Product Specification
| Host | Mouse |
| Antigen | CD45R/B220 |
| Synonyms | Receptor-type tyrosine-protein phosphatase C; Leukocyte common antigen (L-CA); Lymphocyte antigen 5 (Ly-5); T200; CD45; Ly-5; Ptprc |
| Location | Cell membrane, Synapse |
| Accession | P06800 |
| Clone Number | S-R521 |
| Antibody Type | Mouse mAb |
| Isotype | IgG2a,k |
| Application | FCM |
| Reactivity | Ms |
| Positive Sample | SJL mouse splenocytes |
| Purification | Protein A |
| Concentration | 0.2 mg/ml |
| Conjugation | APC |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 1% BSA, 0.3% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 ยฐC as supplied |
Dilution
| application | dilution | species |
| FCM | 5ฮผl per million cells in 100ฮผl volume | Ms |
Background
CD45.1 is a variant of CD45 (Leukocyte Common Antigen), a protein tyrosine phosphatase (PTP) family member with a molecular weight of approximately 180โ240 kDa. It is broadly expressed on the surface of all hematopoietic cells except mature erythrocytes and platelets. Encoded by the Ptprca allele, CD45.1 differs in amino acid sequence from the more common CD45.2 (encoded by Ptprcb) and is primarily expressed in mouse strains such as SJL/J, RIII, STS/A, and DA. Functionally, CD45.1 plays a crucial role in immune cell signaling by modulating T-cell receptor (TCR) and B-cell receptor (BCR) pathways, thereby influencing cell activation, proliferation, and differentiation. Due to its differential expression compared to CD45.2, CD45.1 mouse models (e.g., B6-Ly5.1) are widely used in cell transplantation tracking experiments to distinguish donor and recipient cells. These models are valuable in tumor immunology, autoimmune disease research, and hematopoietic development studies.
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