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Description
SOX10 Recombinant Rabbit mAb (Alexa Fluor® 647 Conjugate) (SDT-R233)Product Specification Host Rabbit Antigen SOX10 Synonyms Transcription factor SOX 10 Location Cytoplasm, Nucleus Accession P56693 Clone Number SDT R233 Antibody Type Recombinant mAb Isotype IgG Application ICC, IF, ICFCM Reactivity Hu, Ms, Rt Positive Sample A375 Purification Protein A Concentration 2 mg ml Conjugation Alexa Fluor 647 Physical Appearance Liquid Storage Buffer PBS, 1% BSA, 0. 3% Proclin 300 Stability & Storage 12 months from date of
Product Specification
| Host | Rabbit |
| Antigen | SOX10 |
| Synonyms | Transcription factor SOX-10 |
| Location | Cytoplasm, Nucleus |
| Accession | P56693 |
| Clone Number | SDT-R233 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | ICC, IF, ICFCM |
| Reactivity | Hu, Ms, Rt |
| Positive Sample | A375 |
| Purification | Protein A |
| Concentration | 2 mg/ml |
| Conjugation | Alexa Fluor® 647 |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 1% BSA, 0.3% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| ICC | 1:200 | Hu |
| IF | 1:200 | Hu, Ms, Rt |
| ICFCM | 1:2000 | Hu |
Background
SOX10 (SRY-box transcription factor 10) is a 55-kDa member of the SOX family of high-mobility-group (HMG) DNA-binding transcription factors that acts as a master regulator of neural crest development, melanocyte specification, and oligodendrocyte differentiation by forming homodimers or heterodimers with other SOX proteins and binding to the consensus sequence A/TA/TCAAA/TG, thereby activating or repressing target genes such as MITF, MBP, and PLP1; mutations or chromosomal rearrangements affecting the SOX10 locus on 22q13.1 are linked to the neurocristopathy syndromes Waardenburg–Hirschsprung disease type 4 (WS4), PCWH (peripheral demyelinating neuropathy, central dysmyelinating leukodystrophy, Waardenburg syndrome, and Hirschsprung disease), and a subset of melanoma tumors where SOX10 serves as a sensitive and specific immunohistochemical marker, while its expression is also essential for the maintenance of Schwann cell and melanocyte lineages throughout adulthood.
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